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Reel/Frame:	022960/0670			Pages:	20
		Recorded:	07/17/2009
Attorney Dkt #:	44211-54099
Conveyance:	SECURITY AGREEMENT

Total properties: 33

1

Patent #:	5690907	Issue Dt:	11/25/1997	Application #:	08488743	Filing Dt:	06/08/1995
Title:	AVIDIN-BIOTIN CONJUGATED EMULSIONS AS A SITE SPECIFIC BINDING SYSTEM

2

Patent #:	5780010	Issue Dt:	07/14/1998	Application #:	08647277	Filing Dt:	05/23/1996
Title:	METHOD OF MRI USING AVIDIN-BIOTIN CONJUGATED EMULSIONS AS A SITE SPECIFIC BINDING SYSTEM

3

Patent #:	5958371	Issue Dt:	09/28/1999	Application #:	08989979	Filing Dt:	12/12/1997
Title:	SITE SPECIFIC BINDING SYSTEM, NUCLEAR IMAGING COMPOSITIONS AND METHODS

4

Patent #:	5989520	Issue Dt:	11/23/1999	Application #:	09026216	Filing Dt:	02/19/1998
Title:	SITE SPECIFIC BINDING SYSTEM, IMAGING COMPOSITIONS AND METHOD

5

Patent #:	6548046	Issue Dt:	04/15/2003	Application #:	09404963	Filing Dt:	09/24/1999
Title:	SITE SPECIFIC BINDING SYSTEM, IMAGING COMPOSITIONS AND METHODS

6

Patent #:	6676963	Issue Dt:	01/13/2004	Application #:	09697796	Filing Dt:	10/27/2000
Title:	LIGAND-TARGETED EMULSIONS CARRYING BIOACTIVE AGENTS

7

Patent #:	7179449	Issue Dt:	02/20/2007	Application #:	09774278	Filing Dt:	01/30/2001
Publication #:	US20020102216	Pub Dt:	08/01/2002
Title:	ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE-DEPENDENT CONTRAST AGENTS

8

Patent #:	6821506	Issue Dt:	11/23/2004	Application #:	10036317	Filing Dt:	12/28/2001
Publication #:	US20020168320	Pub Dt:	11/14/2002
Title:	SITE SPECIFIC BINDING SYSTEM, IMAGING COMPOSITIONS AND METHODS

9

Patent #:	6869591	Issue Dt:	03/22/2005	Application #:	10153395	Filing Dt:	05/21/2002
Publication #:	US20030185760	Pub Dt:	10/02/2003
Title:	PARAMAGNETIC PARTICLES THAT PROVIDE IMPROVED RELAXIVITY

10

Patent #:	7220401	Issue Dt:	05/22/2007	Application #:	10225024	Filing Dt:	08/20/2002
Publication #:	US20030086867	Pub Dt:	05/08/2003
Title:	BLOOD CLOT-TARGETED NANOPARTICLES

11

Patent #:	7186399	Issue Dt:	03/06/2007	Application #:	10302369	Filing Dt:	11/22/2002
Publication #:	US20030129136	Pub Dt:	07/10/2003
Title:	METHODS FOR TARGETED DRUG DELIVERY

12

Patent #:	7255875	Issue Dt:	08/14/2007	Application #:	10351463	Filing Dt:	01/24/2003
Publication #:	US20040058951	Pub Dt:	03/25/2004
Title:	INTEGRIN TARGETED IMAGING AGENTS

13

Patent #:	7235227	Issue Dt:	06/26/2007	Application #:	10400379	Filing Dt:	03/26/2003
Publication #:	US20030215392	Pub Dt:	11/20/2003
Title:	PARAMAGNETIC PARTICLES THAT PROVIDE IMPROVED RELAXIVITY

14

Patent #:	7803374	Issue Dt:	09/28/2010	Application #:	10492749	Filing Dt:	08/30/2006
Publication #:	US20070010577	Pub Dt:	01/11/2007
Title:	TARGETED ATHEROSCLEROSIS TREATMENT

15

Patent #:	NONE	Issue Dt:		Application #:	10544857	Filing Dt:	09/25/2007
Publication #:	US20080247943	Pub Dt:	10/09/2008
Title:	Blood Clot-Targeted Nanoparticles

16

Patent #:	NONE	Issue Dt:		Application #:	10588572	Filing Dt:	11/30/2007
Publication #:	US20080193372	Pub Dt:	08/14/2008
Title:	Efficacy and Safety of Targeted Particulate Agents with Decoy Systems

17

Patent #:	7279150	Issue Dt:	10/09/2007	Application #:	10765299	Filing Dt:	01/26/2004
Publication #:	US20040248856	Pub Dt:	12/09/2004
Title:	CHELATING AGENTS WITH LIPOPHILIC CARRIERS

18

Patent #:	NONE	Issue Dt:		Application #:	10913846	Filing Dt:	08/06/2004
Publication #:	US20050079131	Pub Dt:	04/14/2005
Title:	Emulsion particles for imaging and therapy and methods of use thereof

19

Patent #:	NONE	Issue Dt:		Application #:	10993578	Filing Dt:	11/19/2004
Publication #:	US20050175541	Pub Dt:	08/11/2005
Title:	Enhanced drug delivery

20

Patent #:	7504088	Issue Dt:	03/17/2009	Application #:	11146651	Filing Dt:	06/07/2005
Publication #:	US20060008417	Pub Dt:	01/12/2006
Title:	LIPOPHILIC DERIVATIVES OF CHELATE MONOAMIDES

21

Patent #:	7344698	Issue Dt:	03/18/2008	Application #:	11305416	Filing Dt:	12/16/2005
Publication #:	US20060147380	Pub Dt:	07/06/2006
Title:	INTEGRIN TARGETED IMAGING AGENTS

22

Patent #:	NONE	Issue Dt:		Application #:	11607683	Filing Dt:	12/01/2006
Publication #:	US20070140965	Pub Dt:	06/21/2007
Title:	Methods to ameliorate and image angioplasty-induced vascular injury

23

Patent #:	NONE	Issue Dt:		Application #:	11677040	Filing Dt:	02/20/2007
Publication #:	US20070255117	Pub Dt:	11/01/2007
Title:	ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE-DEPENDENT CONTRAST AGENTS

24

Patent #:	8003078	Issue Dt:	08/23/2011	Application #:	11693647	Filing Dt:	03/29/2007
Publication #:	US20070237721	Pub Dt:	10/11/2007
Title:	TARGETED MR IMAGING AGENTS

25

Patent #:	NONE	Issue Dt:		Application #:	11796064	Filing Dt:	04/25/2007
Publication #:	US20070202040	Pub Dt:	08/30/2007
Title:	Blood clot-targeted nanoparticles

26

Patent #:	NONE	Issue Dt:		Application #:	11796415	Filing Dt:	04/27/2007
Publication #:	US20070258908	Pub Dt:	11/08/2007
Title:	Detection and imaging of target tissue

27

Patent #:	NONE	Issue Dt:		Application #:	11865603	Filing Dt:	10/01/2007
Publication #:	US20080138288	Pub Dt:	06/12/2008
Title:	COMBINATIONS FOR TREATMENT OF NEOVASCULATURE

28

Patent #:	7727512	Issue Dt:	06/01/2010	Application #:	11869685	Filing Dt:	10/09/2007
Publication #:	US20080145311	Pub Dt:	06/19/2008
Title:	CHELATING AGENTS WITH LIPOPHILIC CARRIERS

29

Patent #:	7998462	Issue Dt:	08/16/2011	Application #:	11872984	Filing Dt:	10/16/2007
Publication #:	US20080305037	Pub Dt:	12/11/2008
Title:	LINKERS FOR ANCHORING TARGETING LIGANDS

30

Patent #:	NONE	Issue Dt:		Application #:	11944271	Filing Dt:	11/21/2007
Publication #:	US20080241061	Pub Dt:	10/02/2008
Title:	METHODS OF IMAGING EMPLOYING CHELATING AGENTS

31

Patent #:	7566442	Issue Dt:	07/28/2009	Application #:	11971818	Filing Dt:	01/09/2008
Publication #:	US20080175792	Pub Dt:	07/24/2008
Title:	INTEGRIN TARGETED IMAGING AGENTS

32

Patent #:	7943168	Issue Dt:	05/17/2011	Application #:	12043063	Filing Dt:	03/05/2008
Publication #:	US20080274056	Pub Dt:	11/06/2008
Title:	NANOPARTICLE DELIVERY SYSTEMS COMPRISING A HYDROPHOBIC CORE AND A LIPID/SURFACTANT LAYER COMPRISING A MEMBRANE-LYTIC PEPTIDE

33

Patent #:	NONE	Issue Dt:		Application #:	12160091	Filing Dt:	11/03/2008
Publication #:	US20090317475	Pub Dt:	12/24/2009
Title:	COMBINATION ANTITUMOR THERAPIES

Assignor

1

Exec Dt:

06/12/2009

Assignees

1

PROLOG CAPITAL II, L.P.

7733 FORSYTH BLVD.

SUITE 1440

ST. LOUIS, MISSOURI 63105

2

CHARTER LIFE SCIENCES, L.P.

525 UNIVERSITY AVENUE

SUITE 1400

PALO ALTO, CALIFORNIA 94301

3

MEMPHIS BIOMED VENTURES II, L.P.

17 WEST PONTOTOC

SUITE 200

MEMPHIS, TENNESSEE 38103

4

TRIATHLON MEDICAL VENTURES FUND L.P.

250 EAST 5TH STREET

1100 CHIQUITA CENTER

CINCINNATI, OHIO 45202

5

ADVANTAGE CAPITAL COMMUNITY DEVELOPMENT FUND XV, LLC

7733 FORSYTH BLVD.

SUITE 1850

CLAYTON, MISSOURI 63105

6

ALAFI CAPITAL COMPANY, LLC

P.O. BOX 7338

BERKELEY, CALIFORNIA 94707

7

APJOHN VENTURES FUND, LP

350 E. MICHIGAN AVENUE

SUITE 500

KALAMAZOO, MICHIGAN 48301

8

VECTIS LIFE SCIENCES FUND I, L.P.

84 STATE STREET

BOSTON, MASSACHUSETTS 02109

9

WICKLINE, SAMUEL A., M.D.

11211 POINTE COURT

ST. LOUIS, MISSOURI 63127

10

1998 CO-INVESTING LLC

1034 S. BRENTWOOD BLVD.

SUITE 1860

ST. LOUIS, MISSOURI 63117

11

C. AGANOSTOPOULOS REVOCABLE TRUST U/A 12/21/1978

3959 MOUNT SERVON DRIVE

BLOOMFIELD HILLS, MICHIGAN 48301

Correspondence name and address
	TIFFANY L. SCHWARTZ
	ONE US BANK PLAZA
	ST. LOUIS, MO 63101

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