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Reel/Frame:	051722/0304			Pages:	10
		Recorded:	01/28/2020
Attorney Dkt #:	034093.00019
Conveyance:	RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS).

Total properties: 65

1

Patent #:	4873316	Issue Dt:	10/10/1989	Application #:	07065994	Filing Dt:	06/23/1987
Title:	EXPRESSION OF EXOGENOUS RECOMBINANT PROTEINS FROM THE MILK OF TRANS- GENIC MAMMALS

2

Patent #:	4994384	Issue Dt:	02/19/1991	Application #:	07113791	Filing Dt:	10/27/1987
Title:	MULTIPLYING BOVINE EMBRYOS

3

Patent #:	5304489	Issue Dt:	04/19/1994	Application #:	07602066	Filing Dt:	10/24/1990
Title:	DNA SEQUENCES TO TARGET PROTEINS TO THE MAMMARY GLAND FOR EFFICIENT SECRETION

4

Patent #:	5366894	Issue Dt:	11/22/1994	Application #:	07796439	Filing Dt:	11/22/1991
Title:	PEPTIDE PRODUCTION

5

Patent #:	5322775	Issue Dt:	06/21/1994	Application #:	07796917	Filing Dt:	11/22/1991
Title:	PEPTIDE PRODUCTION

6

Patent #:	5476995	Issue Dt:	12/19/1995	Application #:	07931864	Filing Dt:	08/18/1992
Title:	PEPTIDE PRODUCTION

7

Patent #:	5612205	Issue Dt:	03/18/1997	Application #:	07989002	Filing Dt:	03/01/1993
Title:	HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

8

Patent #:	5496720	Issue Dt:	03/05/1996	Application #:	08016703	Filing Dt:	02/10/1993
Title:	PARTHENOGENIC OOCYTE ACTIVATION

9

Patent #:	5453366	Issue Dt:	09/26/1995	Application #:	08031815	Filing Dt:	03/15/1993
Title:	METHOD OF CLONING BOVINE EMBRYOS

10

Patent #:	5633076	Issue Dt:	05/27/1997	Application #:	08154019	Filing Dt:	11/16/1993
Title:	METHOD OF PRODUCING A TRANSGENIC BOVINE OR TRANSGENIC BOVINE EMBRYO

11

Patent #:	5565362	Issue Dt:	10/15/1996	Application #:	08185574	Filing Dt:	01/24/1994
Title:	DNA SEQUENCES TO TARGET PROTEINS TO THE MAMMARY GLAND FOR EFFICIENT SECRETION

12

Patent #:	5994616	Issue Dt:	11/30/1999	Application #:	08186836	Filing Dt:	01/25/1994
Title:	TARGETED SYNTHESIS OF PROTEIN IN MAMMARY GLAND OF A NON-HUMAN TRANSGENIC MAMMAL

13

Patent #:	5639940	Issue Dt:	06/17/1997	Application #:	08206176	Filing Dt:	03/03/1994
Title:	PRODUCTION OF FIBRINOGEN IN TRANSGENIC ANIMALS

14

Patent #:	6727405	Issue Dt:	04/27/2004	Application #:	08246259	Filing Dt:	05/19/1994
Title:	TRANSGENIC ANIMALS SECRETING DESIRED PROTEINS INTO MILK

15

Patent #:	5576040	Issue Dt:	11/19/1996	Application #:	08282256	Filing Dt:	07/29/1994
Title:	PROCESS FOR THE STERILE FILTRATION OF MILK

16

Patent #:	5959171	Issue Dt:	09/28/1999	Application #:	08291074	Filing Dt:	08/17/1994
Title:	METHOD FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE POLYPEPTIDES IN A MAMMAL'S MILK AS FUSION PROTEINS THAT ARE LESS ACTIVE THAN THE FREE POLYPEPTIDES, OR NON-ACTIVE

17

Patent #:	5861299	Issue Dt:	01/19/1999	Application #:	08343884	Filing Dt:	11/17/1994
Title:	GENETIC CONSTRUCT OF WHICH PROTEIN CODING DNA COMPRISES INTRONS AND IS DESIGNED FOR PROTEIN PRODUCTION IN TRANSGENIC ANIMALS

18

Patent #:	5650503	Issue Dt:	07/22/1997	Application #:	08359854	Filing Dt:	12/20/1994
Title:	GENETIC CONSTRUCT OF WHICH PROTEIN CODING DNA COMPRISES INTRONS AND IS DESIGNED FOR PROTEIN PRODUCTION IN TRANSGENIC ANIMALS

19

Patent #:	5852224	Issue Dt:	12/22/1998	Application #:	08381691	Filing Dt:	01/31/1995
Title:	ALPHA-LACTALBUMIN GENE CONSTRUCTS

20

Patent #:	5919913	Issue Dt:	07/06/1999	Application #:	08406271	Filing Dt:	03/09/1995
Title:	ISOLATION OF LACTOFERRIN FROM MILK

21

Patent #:	5750172	Issue Dt:	05/12/1998	Application #:	08460959	Filing Dt:	06/05/1995
Title:	TRANSGENIC NON-HUMAN MAMMAL MILK

22

Patent #:	5741957	Issue Dt:	04/21/1998	Application #:	08461333	Filing Dt:	06/05/1995
Title:	TRANSGENIC BOVINE

23

Patent #:	5721367	Issue Dt:	02/24/1998	Application #:	08462986	Filing Dt:	06/05/1995
Title:	HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

24

Patent #:	6013857	Issue Dt:	01/11/2000	Application #:	08464167	Filing Dt:	06/05/1995
Title:	TRANSGENIC BOVINES AND MILK FROM TRANSGENIC BOVINES

25

Patent #:	5849885	Issue Dt:	12/15/1998	Application #:	08464182	Filing Dt:	06/05/1995
Title:	ISOLATION OF LACTOFERRIN FROM MILK

26

Patent #:	5962648	Issue Dt:	10/05/1999	Application #:	08473465	Filing Dt:	06/07/1995
Title:	PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC MAMMALS

27

Patent #:	5843754	Issue Dt:	12/01/1998	Application #:	08473794	Filing Dt:	06/06/1995
Title:	PARTHENOGENIC BOVINE OOCYTE ACTIVATION

28

Patent #:	6140552	Issue Dt:	10/31/2000	Application #:	08476798	Filing Dt:	06/07/1995
Title:	PRODUCTION OF RECOMBINANT POLYPEPTIDES BY BOVINE SPECIES AND TRANSGENIC METHODS

29

Patent #:	6713662	Issue Dt:	03/30/2004	Application #:	08482173	Filing Dt:	06/07/1995
Title:	PRODUCTION OF COLLAGEN IN THE MILK OF TRANSGENIC MAMMALS

30

Patent #:	5895833	Issue Dt:	04/20/1999	Application #:	08485194	Filing Dt:	06/07/1995
Title:	PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC ANIMALS

31

Patent #:	6495344	Issue Dt:	12/17/2002	Application #:	08545573	Filing Dt:	01/16/1996
Publication #:	US20020192744	Pub Dt:	12/19/2002
Title:	PHENYLALANINE-FREE PROTEIN AND DNA CODING THEREFOR

32

Patent #:	6194202	Issue Dt:	02/27/2001	Application #:	08610744	Filing Dt:	03/04/1996
Title:	PARTHENOGENIC OOCYTE ACTIVATION

33

Patent #:	6268487	Issue Dt:	07/31/2001	Application #:	08648235	Filing Dt:	05/13/1996
Title:	PURIFICATION OF BIOLOGICALLY ACTIVE PEPTIDES FROM MILK

34

Patent #:	5861491	Issue Dt:	01/19/1999	Application #:	08693274	Filing Dt:	10/16/1996
Title:	ISOLATION OF LACTOFERRIN FROM MILK

35

Patent #:	6118045	Issue Dt:	09/12/2000	Application #:	08700760	Filing Dt:	07/29/1996
Title:	LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF TRANSGENIC ANIMALS

36

Patent #:	6211427	Issue Dt:	04/03/2001	Application #:	08727153	Filing Dt:	10/08/1996
Title:	PIPTIDE PRODUCTION AS FUSION PROTEIN IN TRANSGENIC MAMMAL MILK

37

Patent #:	6046380	Issue Dt:	04/04/2000	Application #:	08742877	Filing Dt:	11/01/1996
Title:	FACTOR 1X PRODUCTION IN TRANSGENIC NON-HUMAN MAMMALS AND FACTOR 1X DNA SEQUENCES WITH MODIFIED SPLICE SITES

38

Patent #:	6548735	Issue Dt:	04/15/2003	Application #:	08781518	Filing Dt:	01/09/1997
Title:	PRODUCTION OF HETEROLOGOUS PROTEIN IN MILK OF TRANSGENIC NON-HUMAN MAMMALS COMPRISING A CONSTRUCT WITH AN INTRON

39

Patent #:	6197946	Issue Dt:	03/06/2001	Application #:	08938595	Filing Dt:	09/25/1997
Title:	PEPTIDE PRODUCTION AS FUSION PROTEIN IN TRANSGENIC MAMMAL MILK

40

Patent #:	6333311	Issue Dt:	12/25/2001	Application #:	09017043	Filing Dt:	02/02/1998
Title:	USEFUL PROPERTIES OF HUMAN LACTOFERRIN AND VARIANTS THEREOF

41

Patent #:	6194553	Issue Dt:	02/27/2001	Application #:	09036796	Filing Dt:	03/09/1998
Title:	PURIFICATION OF ALPHA-1 PROTEINASE INHIBITOR

42

Patent #:	6066725	Issue Dt:	05/23/2000	Application #:	09158313	Filing Dt:	09/21/1998
Title:	PRODUCTION OF RECOMBINANT POLYPEPTIDES BY BOVINE SPECIES AND TRANSGENIC METHODS

43

Patent #:	6077710	Issue Dt:	06/20/2000	Application #:	09176395	Filing Dt:	10/21/1998
Title:	PARTHENOGENIC OOCYTE ACTIVATION

44

Patent #:	6641526	Issue Dt:	11/04/2003	Application #:	09177391	Filing Dt:	10/23/1998
Title:	DEVELOPMENT OF NORMAL OFFSPRING FORM OOCYTES INJECTED WITH FREEZE-DRIED SPERMATOZOA

45

Patent #:	RE42704	Issue Dt:	09/13/2011	Application #:	09232488	Filing Dt:	01/15/1999
Title:	PRODUCTION OF FIBRINOGEN IN TRANSGENIC ANIMALS

46

Patent #:	6111165	Issue Dt:	08/29/2000	Application #:	09232740	Filing Dt:	01/15/1999
Title:	PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC ANIMALS

47

Patent #:	6011197	Issue Dt:	01/04/2000	Application #:	09239922	Filing Dt:	01/28/1999
Title:	METHOD OF CLONING BOVINES USING REPROGRAMMED NON-EMBRYONIC BOVINE CELLS

48

Patent #:	6395958	Issue Dt:	05/28/2002	Application #:	09354276	Filing Dt:	07/15/1999
Title:	METHOD OF PRODUCING A POLYPEPTIDE IN AN UNGULATE

49

Patent #:	6525241	Issue Dt:	02/25/2003	Application #:	09355295	Filing Dt:	07/18/1999
Title:	EXPRESSION METHODS

50

Patent #:	6376743	Issue Dt:	04/23/2002	Application #:	09371648	Filing Dt:	08/10/1999
Title:	MAMMALIAN TRANSGENESIS BY INTRACYTOPLASMIC SPERM INJECTION

51

Patent #:	6593139	Issue Dt:	07/15/2003	Application #:	09478848	Filing Dt:	01/07/2000
Title:	INITIATION OF FULL MAMMALIAN OOCYTE ACTIVATION BY MULTIPLE SPERM COMPONENTS

52

Patent #:	6680199	Issue Dt:	01/20/2004	Application #:	09576592	Filing Dt:	05/22/2000
Title:	IN VITRO ACTIVATION OF MAMMALIAN OOCYTES

53

Patent #:	6525176	Issue Dt:	02/25/2003	Application #:	09612592	Filing Dt:	07/07/2000
Title:	PURIFICATION OF ALPHA-1 PROTEINASE INHIBITOR

54

Patent #:	6603059	Issue Dt:	08/05/2003	Application #:	09688782	Filing Dt:	10/16/2000
Title:	UNGULATES PRODUCED BY SEQUENTIAL NUCLEAR TRANSFER

55

Patent #:	7030289	Issue Dt:	04/18/2006	Application #:	09861399	Filing Dt:	05/18/2001
Publication #:	US20030088881	Pub Dt:	05/08/2003
Title:	STABILISATION OF MILK FROM TRANSGENIC ANIMALS

56

Patent #:	7045677	Issue Dt:	05/16/2006	Application #:	10024597	Filing Dt:	12/21/2001
Publication #:	US20030167477	Pub Dt:	09/04/2003
Title:	FUSION PROTEINS INCORPORATING LYSOZYME

57

Patent #:	7067713	Issue Dt:	06/27/2006	Application #:	10181704	Filing Dt:	07/17/2002
Publication #:	US20030140358	Pub Dt:	07/24/2003
Title:	C1 INHIBITOR PRODUCED IN THE MILK OF TRANSGENIC NON--HUMAN MAMMALS

58

Patent #:	7544853	Issue Dt:	06/09/2009	Application #:	10557026	Filing Dt:	02/21/2007
Publication #:	US20070185011	Pub Dt:	08/09/2007
Title:	C1 INHIBITOR WITH SHORT HALF-LIFE TRANSIENT TREATMENT

59

Patent #:	8071532	Issue Dt:	12/06/2011	Application #:	12158987	Filing Dt:	06/23/2008
Publication #:	US20080305993	Pub Dt:	12/11/2008
Title:	USE OF C1 INHIBITOR FOR THE PREVENTION OF ISCHEMIA-REPERFUSION INJURY

60

Patent #:	RE43691	Issue Dt:	09/25/2012	Application #:	13157176	Filing Dt:	06/09/2011
Title:	C1 INHIBITOR WITH SHORT HALF-LIFE TRANSIENT TREATMENT

61

Patent #:	8415288	Issue Dt:	04/09/2013	Application #:	13271107	Filing Dt:	10/11/2011
Publication #:	US20120088728	Pub Dt:	04/12/2012
Title:	USE OF C1 INHIBITOR FOR THE PREVENTION OF ISCHEMIA-REPERFUSION INJURY

62

Patent #:	9546381	Issue Dt:	01/17/2017	Application #:	13582044	Filing Dt:	11/06/2012
Publication #:	US20130053546	Pub Dt:	02/28/2013
Title:	Use of Anticoagulants in the Production of Recombinant Proteins in the Milk of Transgenic Animals

63

Patent #:	9211318	Issue Dt:	12/15/2015	Application #:	13776529	Filing Dt:	02/25/2013
Publication #:	US20130244941	Pub Dt:	09/19/2013
Title:	Use Of C1 Inhibitor For The Prevention Of Ischemia-Reperfusion Injury

64

Patent #:	9408366	Issue Dt:	08/09/2016	Application #:	13980283	Filing Dt:	09/30/2013
Publication #:	US20140373786	Pub Dt:	12/25/2014
Title:	MILKING DEVICE

65

Patent #:	NONE	Issue Dt:		Application #:	15122130	Filing Dt:	08/26/2016
Publication #:	US20160361394	Pub Dt:	12/15/2016
Title:	TREATMENT OF HEREDITARY ANGIOEDEMA WITH C1 INHIBITOR

Assignor

1

ORBIMED ROYALTY OPPORTUNITIES II, LP

Exec Dt:

01/23/2020

Assignees

1

PHARMING GROUP N.V.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

2

PHARMING TECHNOLOGIES B.V.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

3

PHARMING INTELLECTUAL PROPERTY B.V.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

4

BROEKMAN INSTITUUT B.V.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

5

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

6

PHARMING AMERICAS B.V.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

7

PHARMING HEALTHCARE, INC.

DARWINWEG 24

2333 CR

LEIDEN, NETHERLANDS

Correspondence name and address
	COVINGTON & BURLING LLP
	ONE CITYCENTER, 850 TENTH STREET, NW
	WASHINGTON, DC 20001

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