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Reel/Frame:	025150/0379			Pages:	34
		Recorded:	10/18/2010
Attorney Dkt #:	36181
Conveyance:	SECURITY AGREEMENT

Total properties: 51

1

Patent #:	5364880	Issue Dt:	11/15/1994	Application #:	08078371	Filing Dt:	06/16/1993
Title:	NOVEL COMPOUND FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

2

Patent #:	5440054	Issue Dt:	08/08/1995	Application #:	08260869	Filing Dt:	06/16/1994
Title:	NOVEL COMPOUND FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

3

Patent #:	5849788	Issue Dt:	12/15/1998	Application #:	08468602	Filing Dt:	06/06/1995
Title:	NOVEL COMPOUND FOR TREATMENT OF CARDIAC ARPHYTHMIA, SYNTHESIS, AND METHODS OF USE

4

Patent #:	6130240	Issue Dt:	10/10/2000	Application #:	09211246	Filing Dt:	12/14/1998
Title:	NOVEL COMPOUND FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

5

Patent #:	6114344	Issue Dt:	09/05/2000	Application #:	09356283	Filing Dt:	07/16/1999
Title:	NOVEL LONG-ACTING LOCAL ANESTHETICS

6

Patent #:	6372783	Issue Dt:	04/16/2002	Application #:	09680873	Filing Dt:	10/06/2000
Title:	Novel enantiomeric compounds for treatment of cardiac arrhythmias and methods of use

7

Patent #:	6316487	Issue Dt:	11/13/2001	Application #:	09680880	Filing Dt:	10/06/2000
Title:	Novel compounds for treatment of cardiac arrhythmia synthesis, and methods of use

8

Patent #:	6362223	Issue Dt:	03/26/2002	Application #:	09684046	Filing Dt:	10/06/2000
Title:	Novel enantiomeric compounds for treatment of cardiac arrhythmias and methods of use

9

Patent #:	6680387	Issue Dt:	01/20/2004	Application #:	09841351	Filing Dt:	04/24/2001
Publication #:	US20030064972	Pub Dt:	04/03/2003
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, AND ATHEROSCLEROSIS

10

Patent #:	6387914	Issue Dt:	05/14/2002	Application #:	09841738	Filing Dt:	04/24/2001
Publication #:	US20020013330	Pub Dt:	01/31/2002
Title:	ULTRASHORT ACTING HYPNOTIC BARBITURATES

11

Patent #:	6469064	Issue Dt:	10/22/2002	Application #:	09841749	Filing Dt:	04/24/2001
Publication #:	US20010056119	Pub Dt:	12/27/2001
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DEPRESSION

12

Patent #:	6552046	Issue Dt:	04/22/2003	Application #:	09876698	Filing Dt:	06/07/2001
Publication #:	US20020025970	Pub Dt:	02/28/2002
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

13

Patent #:	6784199	Issue Dt:	08/31/2004	Application #:	09961538	Filing Dt:	09/21/2001
Publication #:	US20020045620	Pub Dt:	04/18/2002
Title:	ISOXAZOLIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, AND ATHEROSCLEROSIS IN MAMMALS

14

Patent #:	6768008	Issue Dt:	07/27/2004	Application #:	09961542	Filing Dt:	09/21/2001
Publication #:	US20030027798	Pub Dt:	02/06/2003
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, AND ATHEROSCLEROSIS

15

Patent #:	6686377	Issue Dt:	02/03/2004	Application #:	10116320	Filing Dt:	04/03/2002
Publication #:	US20020183343	Pub Dt:	12/05/2002
Title:	ULTRASHORT-ACTING OPIOIDS FOR TRANSDERMAL APPLICATION

16

Patent #:	6683195	Issue Dt:	01/27/2004	Application #:	10123573	Filing Dt:	04/15/2002
Publication #:	US20020193428	Pub Dt:	12/19/2002
Title:	NOVEL ENANTIOMERIC COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND METHODS OF USE

17

Patent #:	6864279	Issue Dt:	03/08/2005	Application #:	10132750	Filing Dt:	04/24/2002
Publication #:	US20030199573	Pub Dt:	10/23/2003
Title:	MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS

18

Patent #:	6683086	Issue Dt:	01/27/2004	Application #:	10145601	Filing Dt:	05/13/2002
Publication #:	US20030100575	Pub Dt:	05/29/2003
Title:	ULTRASHORT ACTING HYPNOTIC BARBITURATES

19

Patent #:	6958355	Issue Dt:	10/25/2005	Application #:	10251522	Filing Dt:	09/20/2002
Publication #:	US20050037997	Pub Dt:	02/17/2005
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, AND ATHEROSCLEROSIS

20

Patent #:	6608097	Issue Dt:	08/19/2003	Application #:	10269139	Filing Dt:	10/10/2002
Publication #:	US20030130330	Pub Dt:	07/10/2003
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF HYPERTENSION AND ANGINA

21

Patent #:	6809116	Issue Dt:	10/26/2004	Application #:	10273702	Filing Dt:	10/18/2002
Publication #:	US20030078284	Pub Dt:	04/24/2003
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DEPRESSION

22

Patent #:	6710070	Issue Dt:	03/23/2004	Application #:	10319073	Filing Dt:	12/10/2002
Publication #:	US20030158194	Pub Dt:	08/21/2003
Title:	NOVEL COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

23

Patent #:	6770655	Issue Dt:	08/03/2004	Application #:	10348669	Filing Dt:	01/21/2003
Publication #:	US20030158221	Pub Dt:	08/21/2003
Title:	NOVEL 5-HT3 RECEPTOR ANTAGONISTS AND METHODS OF USE

24

Patent #:	7265142	Issue Dt:	09/04/2007	Application #:	10643699	Filing Dt:	08/18/2003
Publication #:	US20040034237	Pub Dt:	02/19/2004
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF HYPERTENSION AND ANGINA

25

Patent #:	6818782	Issue Dt:	11/16/2004	Application #:	10697683	Filing Dt:	10/29/2003
Publication #:	US20040097743	Pub Dt:	05/20/2004
Title:	NOVEL ENANTIOMERIC COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND METHODS OF USE

26

Patent #:	7022722	Issue Dt:	04/04/2006	Application #:	10759617	Filing Dt:	01/16/2004
Publication #:	US20050075379	Pub Dt:	04/07/2005
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, AND ATHEROSCLEROSIS

27

Patent #:	7041673	Issue Dt:	05/09/2006	Application #:	10763904	Filing Dt:	01/23/2004
Publication #:	US20040167143	Pub Dt:	08/26/2004
Title:	ULTRASHORT ACTING HYPNOTIC BARBITURATES

28

Patent #:	7001915	Issue Dt:	02/21/2006	Application #:	10771483	Filing Dt:	02/02/2004
Publication #:	US20040162305	Pub Dt:	08/19/2004
Title:	ULTRASHORT-ACTING OPIOIDS FOR TRANSDERMAL APPLICATIONS

29

Patent #:	6869972	Issue Dt:	03/22/2005	Application #:	10799546	Filing Dt:	03/11/2004
Publication #:	US20040176437	Pub Dt:	09/09/2004
Title:	NOVEL COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

30

Patent #:	7145020	Issue Dt:	12/05/2006	Application #:	10822129	Filing Dt:	04/08/2004
Publication #:	US20040220258	Pub Dt:	11/04/2004
Title:	MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS

31

Patent #:	7256191	Issue Dt:	08/14/2007	Application #:	10931586	Filing Dt:	08/31/2004
Publication #:	US20050054676	Pub Dt:	03/10/2005
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF DEPRESSION

32

Patent #:	7176218	Issue Dt:	02/13/2007	Application #:	11031623	Filing Dt:	01/07/2005
Publication #:	US20050176757	Pub Dt:	08/11/2005
Title:	STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS

33

Patent #:	7037933	Issue Dt:	05/02/2006	Application #:	11074152	Filing Dt:	03/07/2005
Publication #:	US20050176805	Pub Dt:	08/11/2005
Title:	NOVEL COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIA, SYNTHESIS, AND METHODS OF USE

34

Patent #:	7282509	Issue Dt:	10/16/2007	Application #:	11087167	Filing Dt:	03/23/2005
Publication #:	US20050197363	Pub Dt:	09/08/2005
Title:	STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS

35

Patent #:	7253208	Issue Dt:	08/07/2007	Application #:	11101714	Filing Dt:	04/08/2005
Publication #:	US20050245603	Pub Dt:	11/03/2005
Title:	MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS

36

Patent #:	7105568	Issue Dt:	09/12/2006	Application #:	11101995	Filing Dt:	04/08/2005
Publication #:	US20050228045	Pub Dt:	10/13/2005
Title:	NOVEL COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIA AND METHODS OF USE

37

Patent #:	7381735	Issue Dt:	06/03/2008	Application #:	11257323	Filing Dt:	10/24/2005
Publication #:	US20060040987	Pub Dt:	02/23/2006
Title:	ULTRASHORT-ACTING OPIOIDS FOR TRANSDERMAL APPLICATION

38

Patent #:	7351842	Issue Dt:	04/01/2008	Application #:	11423559	Filing Dt:	06/12/2006
Publication #:	US20060276535	Pub Dt:	12/07/2006
Title:	NOVEL COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIA AND METHODS OF USE

39

Patent #:	7498449	Issue Dt:	03/03/2009	Application #:	11457719	Filing Dt:	07/14/2006
Publication #:	US20070060640	Pub Dt:	03/15/2007
Title:	ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE

40

Patent #:	7285671	Issue Dt:	10/23/2007	Application #:	11467813	Filing Dt:	08/28/2006
Publication #:	US20060287388	Pub Dt:	12/21/2006
Title:	MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS

41

Patent #:	7326787	Issue Dt:	02/05/2008	Application #:	11469264	Filing Dt:	08/31/2006
Publication #:	US20070078265	Pub Dt:	04/05/2007
Title:	SYNTHETIC METHODS AND INTERMEDIATES FOR STEREOISOMERIC COMPOUNDS USEFUL FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS

42

Patent #:	7501436	Issue Dt:	03/10/2009	Application #:	11551562	Filing Dt:	10/20/2006
Publication #:	US20070197580	Pub Dt:	08/23/2007
Title:	NOVEL 5-HT3 RECEPTOR ANTAGONISTS AND METHODS OF USE

43

Patent #:	8138204	Issue Dt:	03/20/2012	Application #:	11778315	Filing Dt:	07/16/2007
Publication #:	US20080085921	Pub Dt:	04/10/2008
Title:	STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS

44

Patent #:	7666902	Issue Dt:	02/23/2010	Application #:	11778482	Filing Dt:	07/16/2007
Publication #:	US20080027132	Pub Dt:	01/31/2008
Title:	HALOALKYL ESTER DERIVATIVES OF COUMARIN FOR THE TREATMENT OF COAGULATION DISORDERS

45

Patent #:	NONE	Issue Dt:		Application #:	11936620	Filing Dt:	11/07/2007
Publication #:	US20080114059	Pub Dt:	05/15/2008
Title:	Novel Compounds For Treatment of Cardiac Arrhythmia and Methods of Use

46

Patent #:	RE42412	Issue Dt:	05/31/2011	Application #:	11962592	Filing Dt:	12/21/2007
Title:	MATERIALS AND METHODS FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE

47

Patent #:	RE41289	Issue Dt:	04/27/2010	Application #:	12009446	Filing Dt:	12/20/2007
Title:	ULTRASHORT ACTING HYPNOTIC BARBITURATES

48

Patent #:	8093237	Issue Dt:	01/10/2012	Application #:	12047858	Filing Dt:	03/13/2008
Publication #:	US20080255088	Pub Dt:	10/16/2008
Title:	DIBENZO[B,F][1,4]OXAZAPINE COMPOUNDS

49

Patent #:	7629466	Issue Dt:	12/08/2009	Application #:	12109500	Filing Dt:	04/25/2008
Publication #:	US20090137810	Pub Dt:	05/28/2009
Title:	SYNTHETIC METHODS AND INTERMEDIATES FOR STEREOISOMERIC COMPOUNDS USEFUL FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS

50

Patent #:	7932405	Issue Dt:	04/26/2011	Application #:	12268109	Filing Dt:	11/10/2008
Publication #:	US20090082430	Pub Dt:	03/26/2009
Title:	HALOGENATED ESTER DERIVATIVES OF COUMARINS FOR THE TREATMENT OF COAGULATION DISORDERS

51

Patent #:	NONE	Issue Dt:		Application #:	12641954	Filing Dt:	12/18/2009
Publication #:	US20100184815	Pub Dt:	07/22/2010
Title:	AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-ALPHA

Assignor

1

ARYX THERAPEUTICS, INC.

Exec Dt:

08/13/2010

Assignees

1

AYER CAPITAL PARTNERS MASTER FUND, L.P.

230 CALIFORNIA STREET, SUITE 600

AYER CAPITAL MANAGEMENT, L.P. ATTN: JAY VENKATESAN

SAN FRANCISCO, CALIFORNIA 94111

2

MPM BIOVENTURES III, L.P.

200 CLARENDON STREET, 54TH STREET

BOSTON, MASSACHUSETTS 02116

3

MPM BIOVENTURES III-QP, L.P.

200 CLARENDON STREET, 54TH STREET

BOSTON, MASSACHUSETTS 02116

4

MPM BIOVENTURES III GMBH & CO. BETEILIGUNGS KG

200 CLARENDON STREET, 54TH STREET

BOSTON, MASSACHUSETTS 02116

5

MPM BIOVENTURES III PARALLEL FUND, L.P.

200 CLARENDON STREET, 54TH STREET

BOSTON, MASSACHUSETTS 02116

6

AYER CAPITAL PARTNERS KESTREL FUND, L.P.

200 CALIFORNIA STREET, SUITE 600

AYER CAPITAL MANAGEMENT, L.P. ATTN: JAY VENKATESAN

SAN FRANCISCO, CALIFORNIA 94111

7

MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC

200 CLARENDON STREET, 54TH FLOOR

BOSTON, MASSACHUSETTS 02116

Correspondence name and address
	IP RESEARCH PLUS, INC.
	21 TADCASTER CIRCLE
	ATTN: PENELOPE J.A. AGODOA
	WALDORF, MD 20602

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